Most common form of sickle cell disease. Sickle cell anemia is caused by an abnormal type of hemoglobin called hemoglobin S. The red cells contain only hemoglobin S, and no normal hemoglobin A.
The red blood cells contain two abnormal hemoglobins, called hemoglobin S and hemoglobin C.
This variation is similar to sickle cell-SC disease except that an element has been replaced in the hemoglobin molecule. This variation is often also seen in Southeast Asia populations. Some children with hemoglobin E disease are without symptoms. However, under certain conditions, such as exhaustion, hypoxia, severe infection, and/or iron deficiency, some mild to moderate anemia may occur.
This involves an inheritance of both the thalassemia and sickle cell genes. The disorder produces symptoms of moderate anemia and many of the same conditions associated with sickle cell disease.