Von Willebrand Disease
WHAT IS VON WILLEBRAND DISEASE?
Von Willebrand Disease is the most common inherited bleeding disorder in which von Willebrand factor (vWF), a blood protein, is either deficient or defective. Von Willebrand factor is a glue-like protein that interacts with platelets to form a plug which prevents the blood from flowing at the site injury. This is called a platelet plug. If a person does not have enough vWF, or if the factor does not work properly, no platelet plug will form and bleeding will continue for a longer period of time.
Although vWD occurs both in men and women, women are more likely to notice the symptoms because of abnormal bleeding during their menstrual period or after childbirth. The disorder can be inherited from either parent.
It has been estimated that vWD affects up to one percent of the population. However, it is generally the least severe of the clotting disorders. Many people with vWD will have few, if any, symptoms. The main symptoms are easy bruising, frequent or prolonged nosebleeds, increased menstrual bleeding, and prolonged bleeding following injury, surgery, dental work, or childbirth.